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Bert Powers's avatar

It has been a slow and tragic awakening.

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Kim's avatar

One thing I think deserves more focus: there is no "shot" as in, I got THE shot. A BioNTech brochure describes three different platforms for their vaccine: one with uridine (could the body destroy the RNA in this shot?), one with pseudo-uridine (meant to disguise the mRNA from the body) and a third with "self-amplifying" mRNA (contains two open reading frames, one codes for antigen protein, the other codes for an RNA-dependent polymerase (and its helper proteins) which self-replicate the mRNA construct in the cell and creates multiple self-copies. Self replicating RNA generates 64 times the amount of antigen (spike) compared to non-amplifying RNA.

So at the very least, one could expect not all three platforms would generate the same adverse effects. This would certainly keep me from going back for a second shot. It looks more like Russian Roulette than getting a singular shot.

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